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Postdoctoral Position – RNA Biology & Cancer
Dr. Olga Anczuków, PhD, Assistant Professor
The Jackson Laboratory for Genomic Medicine, CT
About the position: We are looking for talented postdoctoral candidates to investigate how misregulation of alternative RNA splicing contributes to human disease, with a specific focus on cancer. The positions are fully funded through two NIH grants, and awaiting the proper, enthusiastic applicant.
Our research goals are to: i) define the molecular pathways that regulate splicing factors in normal and cancer cells, as well as during cell differentiation; ii) uncover causal splicing alterations in breast tumors; and iii) identify splicing factors and spliced isoforms which could be used as biomarkers to predict disease progression or drug-response, or as targets for RNA-based therapeutics. Our research uses 3D cell culture models, mouse models including patient-derived xenograft, as well as large clinical datasets, and leverages cutting-edge approaches such as RNA-targeting CRISPR, short- and long-read RNA-sequencing, and single-cell approaches, to decipher the role of spliced isoforms and their regulators.
Our research group, consisting of a postdoctoral associate, two graduate students, and two research associates, is diverse and collaborative. We seek to produce top notch science and foster the development of outstanding, independent scientists through nurturing mentorship and interdisciplinary, collaborative efforts. We have close collaboration with members of the JAX NCI-designated Cancer Center and the Nathan Shock Excellence of Research on Aging Center. For more, visit the Anczuków Lab online.