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Postdoctoral Position – RNA Biology & Cancer
Dr. Olga Anczuków, PhD, Assistant Professor
The Jackson Laboratory for Genomic Medicine, CT
About the position: We are looking for talented postdoctoral candidates to investigate how misregulation of alternative RNA splicing contributes to human disease, with a specific focus on cancer. The positions are fully funded through two NIH grants, and awaiting the proper, enthusiastic applicant.
Our research goals are to: i) define the molecular pathways that regulate splicing factors in normal and cancer cells, as well as during cell differentiation; ii) uncover causal splicing alterations in breast tumors; and iii) identify splicing factors and spliced isoforms which could be used as biomarkers to predict disease progression or drug-response, or as targets for RNA-based therapeutics. Our research uses 3D cell culture models, mouse models including patient-derived xenograft, as well as large clinical datasets, and leverages cutting-edge approaches such as RNA-targeting CRISPR, short- and long-read RNA-sequencing, and single-cell approaches, to decipher the role of spliced isoforms and their regulators.
Our research group, consisting of a postdoctoral associate, two graduate students, and two research associates, is diverse and collaborative. We seek to produce top notch science and foster the development of outstanding, independent scientists through nurturing mentorship and interdisciplinary, collaborative efforts. We have close collaboration with members of the JAX NCI-designated Cancer Center and the Nathan Shock Excellence of Research on Aging Center. For more, visit the Anczuków Lab online.
Associate Research Scientist
Dr. Paul Robson’s Single Cell Biology Laboratory within the Scientific Services, at The Jackson Laboratory, Bar Harbor, ME is seeking a PhD-level Associate Research Scientist to develop and apply single cell technologies and advise others in the technical aspects of such studies. Technologies span genomic, epigenomic, transcriptomic, proteomic, and multi-omic methods, all with the intent to understand biology at single cell resolution. These technologies will largely be employed to characterize the genetic and cellular diversity in the extensive mouse models available here at JAX. Areas of biology include but are not limited to developmental, reproductive, and stem cell biology, cancer, aging, and neurogenetics. This position would be an integral member of the larger single cell biology team that spans both the Bar Harbor, ME and Farmington, CT JAX campuses, aimed at integrating mouse and human biology at single cell resolution.
The Kaczorowski Lab at The Jackson Laboratory is seeking an Associate Research Scientist to support our ongoing research program and to develop new research projects. Our group primarily focuses on mechanisms of learning and memory, as well as genetic diseases of aging (Alzheimer’s and related dementias). The successful candidate will continue and extend studies of the molecular signatures that underlie learning and memory, and disease-related pathological changes in translational models of Alzheimer’s disease. The applicant must be a team player with exceptional organizational and project management skills, including the ability to plan, schedule, and successfully carry out multiple projects at the same time. In addition to experimental studies, the applicant is expected to participate in manuscript preparation and grant writing, and will be strongly encouraged to obtain independent funding.
Title: Postdoctoral Position
Institution: Jackson Laboratory for Genomic Medicine
Location: Farmington, CT
PI: Julia Oh, Ph.D. Associate Professor
Send: Cover letter and CV with three references
The Oh lab is seeking motivated computational and/or experimental scientists interested in studying the human microbiome and its impact on health. We seek to use diverse approaches in genomics, bioinformatics, synthetic biology, molecular biology, and microbiology. Our goals are to understand the complexity of our body’s microbial communities and use this information to manipulate the microbiome for therapeutic ends.
Title: Postdoctoral Position
Institution: Jackson Laboratory for Genomic Medicine
Location: Farmington, CT
Send: Cover letter and CV with contact information for three references
The Ucar lab is seeking motivated computational scientists interested in studying how epigenomes of human immune cells change with age and diseases including COVID-19. We use diverse approaches in genomics, bioinformatics, systems biology and immunology to understand how epigenetic regulation of gene expression programs are disrupted by genetics and environment. We are seeking highly-motivated individuals who have prior experience with programming and genomic data analyses. More information can be found at: https://www.ucarlab.com/
How to apply:
• Apply online: https://www.jax.org/careers-and-training/career-opportunities
• Or send your CV and contact information of three references to Dr. Ucar
• Contact information can be found at (https://www.ucarlab.com/)
The Tarchini Lab at The Jackson Laboratory (http://tarchini-lab.org) is seeking a Postdoctoral Associate to complete a team currently composed of two postdocs, one research assistant and rotating students or shorter term trainees. The laboratory focuses on cell polarity mechanisms and their impact on the morphogenesis of sensory “hair” cells in the mouse auditory and vestibular organs, including hearing and balance ability. We are particularly interested in discovering new protein complexes organizing and elongating the stereocilia bundle, the apical hair cell compartment capturing sound or head movements. We are also interested in understanding how these proteins respond to damage, and more generally, to ask whether the molecular machinery assembling the stereocilia bundle during development could be leveraged to regenerate these structures after injury. We are independently funded with two R01 grants from NIH.
The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research (e.g., The Nathan Shock Aging Center and Center for Novel Alzheimer’s Disease Models), unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.
Bar Harbor, ME
A postdoctoral training opportunity is available in the lab of Dr. Gareth Howell at The Jackson Laboratory (JAX) in Bar Harbor, Maine, to study the role of neuroinflammation and vascular health in glaucoma. Dr. Howell’s lab uses genetic and genomic approaches using mouse models to better understand the early stages of neurodegenerative diseases including glaucoma and dementias. A particular focus of this postdoctoral position will be on understanding the mechanisms by which glaucoma risk factors such as aging and intraocular pressure elevation affect the interactions between glial cells (such as astrocytes and microglia) with endothelial cells in the optic nerve head and retina. Dr. Howell, who was recently awarded a BrightFocus National Glaucoma Research Award to understand the role of the CDN2B-AS locus in glaucoma, is a co-PI on an NIH R01 grant with Dr. Richard Libby from the University of Rochester to study the endothelin system in glaucoma, and is the Diana Davis Spencer Foundation Chair for Glaucoma Research. For more information about the work of the Howell lab, visit https://www.jax.org/research-and-faculty/research-labs/the-howell-lab.
The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.
JAX provides excellent educational and training opportunities for postdoctoral associates. Exceptional candidates are encouraged to apply for the prestigious JAX Scholar award, which supports promising early-career postdoctoral associates conducting cutting edge biomedical and basic biological research at JAX. The award includes an independent research and travel budget and a salary above our standard postdoctoral scale (https://www.jax.org/education-and-learning/pre-and-postdoctoral-program/jax-scholars.
Computational Postdoctoral Associate
Bar Harbor, ME
The Carter Lab has an opening for a postdoctoral associate in the computational biology of Alzheimer’s disease. This position is part of an NIH-funded TREAT-AD center, in which our lab plays a leading role in bioinformatics analysis.
The goal of the TREAT-AD consortium (www.treatad.org) is to translate molecular signatures of late-onset Alzheimer’s disease into new treatments. This process encompasses a range of computational and systems biology approaches, including big data analysis through dimensional reduction, inference of disease origin and progression, integration of multiple annotation and data streams to formulate testable hypotheses, and refinement of hypotheses upon collection of additional data. Our collaborative, multi-institutional group is embedded in a large community of researchers focused on data science and stewardship, structural biology, medicinal chemistry, and the neuroscience of disease. The TREAT-AD center is in turn a part of a major open science initiative to understand and treat Alzheimer’s disease that includes the AMP-AD, ADNI, ADSP, and MODEL-AD research consortia. The Carter Lab also has a leading role in MODEL-AD, in which we create new mouse models of late-onset AD for basic research and preclinical testing.
We are especially interested in candidates with systems biology expertise in model organisms who are seeking to apply their innovative ideas in a translational setting. The structure of TREAT-AD enables collaborative follow-up experimentation and refinement of computational hypotheses. We are dedicated to open science and establishing an inclusive culture to expand our vision of scientific progress.
The Jackson Laboratory provides excellent educational and training opportunities for postdoctoral associates. Exceptional candidates are encouraged to apply for the prestigious JAX Scholar award, which supports promising early-career postdoctoral associates conducting cutting edge biomedical and basic biological research at JAX. The award includes an independent research and travel budget and a salary above our standard postdoctoral scale (https://www.jax.org/education-and-learning/pre-and-postdoctoral-program/jax-scholars
To apply, please submit 1) a cover letter outlining research accomplishments and interests, 2) a current CV, and 3) names and contact information for three references.
Bar Harbor, ME
A postdoctoral associate position is available in the laboratory of Dr. Jennifer Trowbridge at The Jackson Laboratory in Bar Harbor, Maine, to study epigenetic mechanisms governing hematopoietic stem cell lineage commitment and how deregulation of epigenetic modifications leads to myeloproliferative disorders including leukemia. The Trowbridge Lab offers a challenging but supportive environment. Past trainees have a noteworthy track record for obtaining grant funding and fellowships. For more information, please visit: https://trowbridgelab.com.
Postdoctoral Associate – Computational Cancer Biology
Dr. Sheng Li’s lab at JAX-GM in Hartford, CT area is seeking a computational biology postdoctoral associate who is interested in studying cancer functional genomics. The Li Lab’s primary interests are computational biology and machine learning with a focus on functional genomics in normal and cancer systems. For additional information, visit the Li Lab online.
Salary is competitive and will be supplemented with funding for computational equipment and for attending national and international conferences.