Reporting to the Manager of Clinical Analytics & Curation, Clinical Genomics, the incumbent will critically evaluate and interpret cancer genomic variants for curation into the JAX Clinical Knowledgebase (JAX-CKB). The variant interpretation scientist will assimilate and integrate data from the scientific literature related to pathogenicity and predictive efficacy evidence in a format compatible with clinical reporting. The content curator will assist in quality assurance and quality control of all data within JAX-CKB.
The Jackson Laboratory is seeking faculty candidates at any rank to pursue a vigorous research program in the field of human stem cell-based tissue engineering at the Genomic Medicine campus in Farmington, CT. The successful candidate will conduct fundamental research to advance the methods and applications of cellular engineering. This position will be deeply connected to on-going research and development efforts of at the Laboratory in the areas of cell and tissue engineering including gene editing, cellular differentiation, tissue printing, tissue-specific organoids, iPSC biology, and cell therapy. Ideal candidates will be collaborative and multidisciplinary in their research approach leveraging multi-campus collaborations and established Jackson Laboratory assets.
The Transgenic Genotyping Service (TGS) has a Genotyping Technician position available working in the Genotyping Lab in Bar Harbor!
The Jackson Laboratory, located in Bar Harbor, ME currently is seeking applicants for the position of Custodian for our 2nd shift – 3:30pm – 12:00am, Monday – Friday typically but applicants must be flexible to accommodate work requirements.
Working under moderate supervision, the custodial position has the primary responsibility of cleaning properties owned or leased by The Jackson Laboratory (JAX) to promote the health and safety of The Jackson Laboratory’s visitors and its employees.
The Neurophysiology Specialist has expertise in establishing, implementing, and executing complex experiments using neurophysiology techniques, including EEG, EMG, and LTP and conducting data analysis and interpretation in support of Neurobehavioral phenotyping in the Center for Biometric Analysis. This is a key position within the Center for Biometric Analysis, requiring project management experience and extensive technical expertise across a multitude of complex phenotyping platforms.
The Senior Strategic Marketing Analyst is responsible for identifying and evaluating new business and new product opportunities both within and outside of currently served markets and technical capabilities. The role requires the ability to work well with teams, help create program visions, and pull and analyze data with ease. The individual will assess market opportunities beyond core adjacencies, and will assist in the prioritization of efforts across disparate business areas. This position is critical to achieving overall business growth goals and will work intimately with New Product Development and Product Management to achieve those goals. The Senior Strategic Marketing Analyst must be able to think deeply about the science associated with each opportunity, and will be a key subject matter expert across multiple therapeutic areas. They must also be capable of leveraging their scientific acumen to rapidly assess potential business opportunities in key adjacencies. This role will report to the Manager, Strategic Marketing.
The Strategic Marketing Analyst is responsible for identifying and evaluating new business and new product opportunities both within and outside of currently served markets and technical capabilities. The role requires the ability to work well with teams, help create program visions, and pull and analyze data with ease. The individual will assess market opportunities beyond core adjacencies, and will assist in the prioritization of efforts across disparate business areas. This position is critical to achieving overall business growth goals and will work intimately with New Product Development and Product Management to achieve those goals. This role will report to the Manager, Strategic Marketing.
Postdoctoral Associate – Computational Cancer Biology
Dr. Sheng Li’s lab at JAX-GM in Hartford, CT area is seeking a computational biology postdoctoral associate who is interested in studying cancer functional genomics. The Li Lab’s primary interests are computational biology and machine learning with a focus on functional genomics in normal and cancer systems. For additional information, visit the Li Lab online.
- Develop principled methods, based on machine learning and advanced statistical modeling techniques to address biological questions.
- Analyze massive functional genomics data at single cell and population levels.
- PhD in Computational Biology, or related quantitative area.
- A strong background in machine learning or substantial experience analyzing large genomic datasets.
- Programming experience in R, Python, or C++.
- Publications in peer-reviewed journals.
- Strong problem-solving skills, excellent communication skills, and enthusiastic about science.
Salary is competitive and will be supplemented with funding for computational equipment and for attending national and international conferences.
The Jackson Laboratory (JAX, www.jax.org) is a nonprofit biomedical research institute with over 2,000 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. A National Cancer Institute-designated Cancer Center, JAX has a mammalian genetics headquarters in Bar Harbor, Maine, a facility in Sacramento, California, and a genomic medicine facility, The Jackson Laboratory for Genomic Medicine (JAX-GM), in Farmington, Connecticut.
JAX-GM is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX-GM’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup.
JAX-GM sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories.
JAX-GM resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX-GM is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports.
JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!
INTEGRITY - Courage and commitment to do what is right
PEOPLE - Inspiring our people to enhance the health of all
ONE TEAM - Unified by our promise to transform medicine and science
EXCELLENCE - Achieving world-class results
INNOVATION - Leading with discovery and creative solutions
STEWARDSHIP - Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program and an onsite full service cafeteria.
Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
Learn more about career opportunities at JAX: http://www.jax.org/careers.
The Jackson Laboratory is a world leader in mammalian genetics, and has a mission we are passionate about: to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
The Munger Lab is seeking a Research Intern with experience in bioinformatics to join The Jackson Laboratory in Bar Harbor, Maine. The Munger Lab explores the interface between genetics and the environment, and how their complex interactions can push gene regulatory networks that drive normal cell differentiation and organ development to an altered disease state. Specifically, we take advantage of genetically diverse mice and stem cells to study how genetic variation in the population impacts multiple layers of gene regulation, with a specific focus on post-transcriptional regulation of protein levels. The primary duties of this position will include developing computational tools and pipelines to integrate and analyze large genetic and genomic datasets. Preference will be given to applicants with proficiency in R or Python programming languages.
We invite highly motivated individuals who are eager to acquire new knowledge and grow new skill sets in a team environment. The Research Intern position offers a very exciting opportunity for junior researchers to grow their research experience and skills broadly and thoroughly. We strongly support research interns for first-authorship/co-authorship in high quality publications, and firmly promote their professional career advancement. The RI position is a temporary position lasting no less than 12 months and up to 36 months and is designed specifically for individuals with a 4-year Life Science, Biology, Computational Biology or applicable degree, looking to advance their scientific/research training prior to pursuing further educational endeavors. During the internship, Research Interns are eligible to apply for permanent positions at JAX as long as performance is rated satisfactory by their Scientific Advisor, but a permanent position is not guaranteed.
*This is not a summer internship*
The Jackson Laboratory (http://www.jax.org) is an independent, nonprofit biomedical research institution internationally recognized for its research excellence and world-class faculty, who perform leading-edge research in the fields of human genomics and mouse genetics. At JAX, our Information Technology is as exciting and progressive as our cutting-edge science. Join our Research IT team to help plan, design, and launch efficient systems in support of scientific research.
We are seeking a DevOps Engineer with solid experience in designing, implementing, and supporting systems used across several dozen laboratories at multiple sites in the organization. The ideal candidate will work as part of a value-stream aligned Agile team to define, create, and adapt solutions for human genomic data, and define systems integrations to meet the rapidly growing and highly integrated needs of laboratory service groups.
Distinguishing factors for level I-III is as follows:
Level I: Entry level Professional that applies broad theoretical job knowledge typically obtained through advanced education. Work is closely supervised and problems faced are not typically difficult or complex. Explains facts, policies and practices related to job area.
Level II: An Experienced Professional that applies practical knowledge of the DevOps discipline typically obtained through advanced education and work experience. Works independently with general supervision, problems faced are difficult but typically not complex. May influence others within the job area through explanation of facts, policies and practices.
Level III: A Senior Professional that applies advanced knowledge of DevOps discipline typically obtained through advanced education and work experience. Manages projects / processes, working independently with limited supervision. Coaches and reviews the work of lower level professionals. Problems faced are difficult and sometimes complex.
Computational Postdoctoral Associate
Computational biology is critical not only to the processing and manipulation of data, but to the scientific discovery process itself. Our lab empowers computational biologists to make discoveries by providing a rich work environment for computational/mathematical analysis of biological systems, access to novel data and computational infrastructure, resources to conduct new experimental measurements, and partnerships with experimental colleagues with shared interests.
As of December 2019, the Chuang Lab is seeking a postdoctoral scientist to join our projects combining computational and experimental approaches to study cancer. Our current projects are at the intersections of cancer biology, machine learning, genomics, image analysis, and pathology. This is a fast-moving field with tremendous opportunities to understand cancer and impact patient outcomes.
New team members will have unique opportunities to investigate mechanisms of cancer, to design new studies, and to develop novel artificial intelligence approaches to mine these data. Our lab seeks to understand how tumor ecology and evolution impact susceptibility and response to immunotherapy, targeted therapy, and chemotherapy. We interrogate these questions by generating data from clinical samples and model systems (xenografts, organoids) and by mining large cancer genomic and imaging datasets using techniques such as deep learning and evolutionary modeling. This position is supported by an R01 grant from the NCI awarded through 2023.
While our lab focuses on computational approaches, we also generate our own data by making use of the extensive scientific services at JAX and in collaboration with many experimental colleagues. These include clinical and experimental groups at JAX (Robson, Palucka, Liu, Anczukow-Camarda, et al.) and with external partners (NCI PDXNet, Yale, Northwestern, UCSD, et al). We have particular access to patient-derived xenografts (PDXs) due to Prof. Chuang's position as co-PI of the National Cancer Institute's PDXNet Consortium Data Commons and Coordination Center, in addition to the extensive data and experimental resources for PDXs at JAX. Thus candidates will have novel opportunities at the intersection of data interpretation, algorithms, and experimental design.
For this position, the ideal candidate will have Ph.D. experience in computational biology, cancer biology, evolutionary biology, digital pathology, or a similar discipline. Outstanding applicants new to computational biology will also be considered as the lab has an extensive record of training candidates who originally studied in other fields, including physics, applied math, computer science, electrical engineering, and experimental molecular biology. A particular area of growth for the lab is the combination of genomic and pathological analysis, and those with a medical background in pathology but a strong interest in computational approaches are encouraged to apply. Computing (programming, data analysis, statistical inference, etc), publication, and communication skills will be essential. Across these backgrounds, enthusiasm and aptitude for computational biology are what define the lab.
Interested and qualified individuals should send a current CV, a 1-page (maximum) Statement of Research Interests and Career Goals, and contact information for 3 references to Dr. Jeff Chuang at firstname.lastname@example.org
Associate Clinical Scientific Curatoror Clinical Scientific Curator
Reporting to the Manager of Clinical Analytics & Curation, Clinical Genomics, the incumbent will critically evaluate and interpret cancer genomic variants for curation into the JAX Clinical Knowledgebase (JAX-CKB). The Clinical Scientific Curator will assimilate and integrate data from the scientific literature related to pathogenicity and predictive efficacy evidence in a format compatible with clinical reporting. The content curator will assist in quality assurance and quality control of all data within JAX-CKB.
The Senior Business Analyst position is responsible for reporting, forecasting and driving coordinated action from analytical insight in line with the goals of the Opportunity Development, Marketing, Business, and Operations teams. This includes proactively identifying, analyzing, and initiating programs to drive revenue growth, cost savings, and enhanced customer value. This position requires the ability to interact with and influence stakeholders across multiple functional groups and multiple levels of leadership. The role reports to the Associate Director, Market Analytics, Strategy, & Product Development.
Verhaak Lab at The Jackson Laboratory
Farmington, CT USA
Tumor evolution, extrachromosomal oncogenes, comparative oncology, single-cell DNA sequencing.
The Verhaak laboratory at the Jackson Laboratory for Genomic Medicine is all about data. Postdoctoral associates have the opportunity to leverage the largest convergence of glioma datasets in the world with an extremely sophisticated computational and technological infrastructure. We have all the latest gimmicks in town: single-cell ATACseq, long-read Nanopore, image mass spectrometry, CRISPR screening: you name it. If you are a PhD-level scientist with first author publications and an interest in cancer genomics, this is for you! We look for candidates with computational expertise and preferable previous work in cancer. We care about talent and about ambition: the goal of your postdoc is to help you achieve your next goals, evidenced by the many alumni who are now independent investigators with their own laboratories. Please look at our lab website: www.verhaaklab.com.
- MD; or PhD in genetics, computational biology, molecular/cell biology, or other quantitative science
- Prior research experience in the following areas will be preferred: cancer, quantitative biology, CRISPR/Cas9 (epi)genome editing, microscopy/imaging, mammalian cell culture and microfluidics processing.
- Track record of productivity supported by first-author publications in peer-reviewed journals
- Outstanding writing and communication skills, with an ability to work both independently and within collaborative teams productively
The Lee laboratory at The Jackson Laboratory for Genomic Medicine in Farmington, CT is seeking a Computational Scientist to join the team; this is an opportunity to be involved in the use of state-of-the-art technologies to study the structural genomic variation in human biology, evolution and disease.
The Computational Scientist will work closely with a team of scientists involved in the ongoing studies which includes; accurate identification and characterization of structural variation (SV) in human and other vertebrate genomes, the development of new algorithm/approach for SV detection, and understanding genome evolution in vertebrate species and its impact on genome stability.
In addition, the Computational Scientist will participate in all Lee Lab activities and collaborations as assigned by the PI of the lab to the extent assigned. They include, and are not limited to, helping interns, post-doctoral fellows, scientists and grant writing. Furthermore, they will present results to The JAX community, at conferences and workshops.
The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research (e.g. The Nathan Shock Aging Center and Center for Novel Alzheimer’s Disease Models), unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT.
The Kaczorowski Lab at The Jackson Laboratory is seeking a Research Assitant II/III with strong experience in molecular and cellular biology to support studies focused on genetic and environmental factors that determine cognitive resilience in aging and Alzheimer’s disease. The successful candidate will be required to culture and maintain primary and transformed cells, extract and assess quality of DNA/RNA, and perform PCR/qPCR, western blots, immunohistochemistry, and ELISA techniques. Additional responsibilities will include technical support for all projects, including next-generation library preparation and genome editing techniques.
The Protein Production and Purification (P3) Service seeks a Research Technician/Technologist to join a new service assisting JAX scientists by the cloning, expression and purification of proteins to be used as antigens and reagents at the Jackson Laboratory in Bar Harbor, Maine. Projects include a combination of mammalian cell culture, chromatography, protein analysis methods, molecular biology, Routine maintenance responsibilities. Although previous experience in these methods is preferred, a candidate with a proven track record of focus, organization, and the ability to follow SOPs while maintaining meticulous records will be considered. This position is a great opportunity for both experienced associates to expand their skills and for energetic new graduates with a passion for research. The salary will be commensurate with experience.
PIs: J. Travis Hinson, M.D. and Michael Stitzel, Ph.D.
The Jackson Laboratory for Genomic Medicine
Preferred start date: Oct 15, 2019- Feb 15, 2020.
The Hinson and Stitzel labs are co-recruiting an independent, highly-motivated PhD-level scientist (<3 years postdoc experience) with a strong background in proteomics and mouse phenotyping to join our expanding research program to study cell type-specific secretomes in health and disease. This collaborative academic project aims to: 1) generate and characterize BioID mouse and human pluripotent stem cell reagents and models using CRISPR technology; and 2) apply quantitative proteomics methods, including Tandem Mass Tags (TMT), to understand cell type-specific communication in vitro and in vivo in healthy and cardiometabolic diseased states.
The Hinson lab at the Jackson Laboratory for Genomic Medicine and UConn Health studies human cardiovascular disorders especially cardiometabolic disorders using a combination of approaches including tissue engineering, genome editing, human pluripotent stem cell technology and genomics assays. The Stitzel lab at the Jackson Laboratory for Genomic Medicine applies innovative functional (epi)genomic approaches to understand the genetic and cellular underpinnings of islet dysfunction in diabetes. We are a highly-collaborative multi-disciplinary team that includes expertise in genome biology, proteomics, computation biology, and clinical cardiometabolic medicine.
**Please submit your current CV, at least 2 letters of reference, and 1-page (maximum) statement of Research Interests and Career Goals at time of application.**
We are a diverse and inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork.
You could make a difference in advancing our mission at The Jackson Laboratory as a Facilities Project Manager based at our Bar Harbor, Maine site as part of the Facilities Engineering team. This full-time professional position will be responsible for managing capital projects from programming through close-out, with primary focus on renovations and new construction across our four campuses with budgets ranging from $20k - $20M. The successful candidate will develop project needs with clients and stakeholders and oversee designers, engineers, contractors, and other resources to assure successful delivery and closeout of each project.
Reporting to the president and CEO and serving as a member of his senior leadership team, the vice president of advancement (vice president) will work closely with this group and other key constituents to set philanthropic strategy for JAX, define a vision for advancement, and design and implement appropriate infrastructure to support a comprehensive, best-practices program that fosters a culture of philanthropy, furthers organizational priorities, retains existing funders, and attracts substantial new philanthropic support from individual and institutional donors as JAX prepares for its next campaign. Additionally, the vice president will personally and successfully engage a select portfolio of high-net-worth prospects and donors.
The vice president may be flexibly based in New England or in the Greater New York region, but will be expected to travel monthly to meet with staff in both Bar Harbor and Farmington. The ideal candidate will be comfortable managing and engaging with staff and colleagues remotely or in satellite offices, and will be adept at using technology, including videoconferencing platforms, to communicate regularly.