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The Palucka Lab at JAX-GM is currently seeking motivated scientists interested in analyzing and integrating RNA-seq, ATAC-seq, and genetic data. Additional tasks will include pre-processing of raw sequencing files, as well as more advanced integrative models using machine learning algorithms.
In addition, JAX Postdoctoral Associates benefit from:
• Research training and mentorship from award-winning faculty
• Individualized career advising and a dedicated Postdoc Program Office
• Superior scientific services and unparalleled mouse resources
• A uniquely collaborative academic research environment
• Guidance from JAX's Postdoctoral Training Committee to help you succeed
• Professional skills workshops including JAX's holistic The Whole Scientist course
• Free access to JAX’s world-renowned Courses & Conferences programs
• Outstanding benefits and salary compensation above the NIH scale
• Generous relocation assistance and free on-campus parking
Postdoctoral position available in
Functional (epi) genomics of pancreatic islet dysfunction in type 2 diabetes
PI: Michael L. Stitzel, Ph.D.
The Jackson Laboratory for Genomic Medicine
The Stitzel lab at The Jackson Laboratory’s Genomic Medicine campus in the Hartford, CT area is seeking an independent, driven PhD-level scientist (<2 years previous postdoc experience) in integrated functional (epi)genomics and/or quantitative genetics to join our growing, externally-funded research program. Our overarching goal is to understand the genetic and cellular underpinnings of islet (dys)function and diabetes. We employ innovative (epi)genomic profiling and single cell genomic technologies, mouse models, and CRISPR/Cas9 (epi)genome editing platforms to identify key genes and pathways controlling human islet cell identity and function and to understand how diabetes-associated DNA sequence variants and environmental stimuli/stressors alter these programs to contribute to islet failure in diabetes.
Interested and qualified individuals should submit a current CV, a 1-page (maximum) Statement of Research Interests and Career Goals, and contact information for 3 references at time of application. Our research group is diverse and collaborative, and we seek to produce top notch science and foster the development of outstanding, independent scientists through critical but nurturing mentorship and interdisciplinary, collaborative efforts.
JAX Genomic Education is currently seeking a full-time Technical Training Specialist to join the Courses & Conferences team in our Bar Harbor, ME location!
This position is responsible for the organization and delivery of hands-on technical training to members of the biomedical research community. Duties focus on educating professional scientists in the practical use of the laboratory mouse and mouse resources in their research. The Training Specialist must have broad knowledge of the use of the laboratory mouse in biomedical research. Participation in the development of novel training programs including new workshops and training materials for distribution to the global scientific community will be a key responsibility. They should also have the ability to cultivate collaborations and long-standing professional relationships with vendors and members of the research community. Significant domestic and international travel is required. Bilingual in English and Mandarin is a plus!
The Necropsy Service has an opening for a full-time position at the Necropsy Technologist I level for our Bar Harbor, ME location!
The Necropsy Technologist will be a collaborative member of a team responsible for supporting JAX internal research programs, requesting necropsy services. Included in these responsibilities is communicating with researchers to understand their project requirements and to develop a standard protocol for their request. The Necropsy Technologist will be able to independently perform requested tissue collections and preparative procedures. This position will also provide training sessions for JAX researchers to teach necropsy, anatomy, dissections and tissue collections.
The Necropsy Technologist will also participate in routine laboratory maintenance (preparing solutions, ensuring workstation and laboratory cleanliness) and perform routine administrative tasks (project documentation, contribute to monthly billing, and ordering supplies).
The position requires a highly motivated individual with a passion for learning and teaching, who works well in a fast paced, deadline-driven environment. Ability to follow established routine procedures and defined schedules, keep records, and work in a team is critical.
The Carter Lab is seeking a postdoctoral associate to join our research in the computational genetics and genomics of complex disease (50% effort) and fill a critical role in our training efforts for the next generation of researchers (50% effort). Our work uses novel, genetically diverse mouse models to understand how genetic factors predispose to disease. We are part of the MODEL-AD consortium (model-ad.org) to create and characterize new Alzheimer’s disease models and the OPEN-AD center to translate ’omics data into potential therapeutics. In addition, we are engaged with a growing bioinformatics training program in JAX Genomic Education to teach researchers in designing experiments and analyzing data with advanced mouse models. We employ evidence-based teaching methods promoted by The Carpentries, an international organization with a mission to train researchers in best practices for data science and computing. For more information about our research, please visit: https://www.jax.org/research-and-faculty/research-labs/the-carter-lab.
The Jackson Laboratory provides excellent educational and training opportunities for postdoctoral associates. Exceptional candidates are encouraged to apply for the prestigious JAX Scholar award, which supports promising early-career postdoctoral associates conducting cutting edge biomedical and basic biological research at JAX. The award includes an independent research and travel budget and a salary above our standard postdoctoral scale (https://www.jax.org/education-and-learning/pre-and-postdoctoral-program/jax-scholars.
This is an exciting opportunity on the Security team at our Sacramento, CA location. This position is responsible for ensuring the safety of all employees, visitors, contractors and guests as well as protecting all property and assets of The Jackson Laboratory. Responsible for staffing and monitoring at assigned post/stations and the Security Operation Center as well performing patrol rounds as assigned and necessary. This individual will respond to emergencies as necessary and providing assistance as needed. Security Services provides 24/7 coverage at The Jackson Laboratory and shift hours may include day/evening/overnight and weekend/holiday hours as required.
Scientific Software Engineer (Associate/Full/Senior)
Data Science Focus
Come join the development team of the JAX Clinical Knowledgebase (CKB). CKB is a dynamic digital resource for interpreting complex cancer genomic profiles and is used by clinicians and researchers from around the world to connect cancer variants to therapies and clinical trials. Come be a part of the fight against Cancer!
This position is available immediately for a Scientific Software Engineer (Associate/Full/Senior) with a large focus on data science, as a part of the Computational Sciences Scientific Computing group at The Jackson Laboratory for Genomic Medicine in Farmington, CT. Play a pivotal role in investigating potential integration opportunities as well as helping to lead the effort to translate those opportunities into mature software solutions. Use your skills to propose, analyze, prototype new solutions as well as run novel analysis over the existing systems. Leverage NLP, ML and AI to develop novel approaches to help streamline curation as well as add additional value to existing data. This is an exciting opportunity to work on challenging problems at the interface of biology, computer science and data science. CKB is a leading cancer knowledgebase, with partners around the world integrating CKB data, join the team and help push CKB to the next level.
The Diagnostic Laboratory at The Jackson Laboratory assures the health and well-being of our animal colonies by routine health monitoring for undesirable infectious agents. Our diagnostic program serves to monitor against potential disease outbreaks in the Production, Research, and Repository colonies, as well as verifying the health status of foster mothers used for rederivation of mouse strains by Reproductive Sciences. The Diagnostic Laboratory also performs environmental monitoring via microbiologic culture of mouse room swabs. This testing strategy includes necropsy, serology, microbiology, and parasitology. The Genetic Quality Control (GQC) Laboratory at The Jackson Laboratory serves to detect and eliminate contamination in the genetic background of all of our Production and Repository colonies by routine and investigative screening using a panel of molecular assays.
This role is crucial to the effective functioning of the Diagnostic & GQC laboratories. The work schedule for the GQC Technician is established based on operational demands and may fluctuate based on the changing needs of the two laboratories, and thus Technicians may be assigned to any of the testing areas (Necropsy, Serology, Microbiology, Parasitology, and GQC) as necessary.
The Diagnostic & GQC Technician works under general supervision, follows standard operating procedures and protocols, and maintains lab inventory by ordering supplies as needed. The Diagnostic & GQC Technician utilizes strong analytical and problem-solving skills and attention to detail to perform complex microbiological testing and molecular assays. The Diagnostic & GQC Technician is capable of trouble-shooting and identifying common problems and issues and assisting supervisor with their resolution.
Safety Technicians are responsible for advising, guiding and providing direct services to staff that use and/or process hazardous materials and hazardous waste, including biological (medical) waste. Provide technical support under direction of EHSS Specialist, to develop, implement and monitor safety programs and regulated processes with goal of protecting the health and safety of JAX employees and maintaining compliance with federal, state and local regulations (OSHA, EPA, DTSC)
The Technician works independently on complex projects with specific guidance from supervisors and managers. Provides initial analysis of data, impact of errors, is proficient in problem solving and suggests corrective actions. Uses wide range of experience and specialized knowledge to works with systems users under the guidance of supervisors and managers to ensure compliance with safety regulations and program requirements.
The Tewhey Lab at The Jackson Laboratory in Bar Harbor, Maine is seeking a Postdoctoral associate to join our team of scientists working to understand the precise genetic mechanisms underlying complex traits, and the impact human genetic variation has on gene regulatory function. Our group develops and applies novel high-throughput genetic techniques (e.g. MPRA and CRISPR based screens) to comprehensively characterize non-coding regions of the genome, in both mouse and human, to interpret the regulatory grammar of gene expression.
The Lu Lab (http://www.lusystemsbio.com) at The Jackson Laboratory is currently seeking motivated and innovative scientists for academic postdoctoral positions at the cutting edge of computational systems biology. The Lu lab, in Bar Harbor, Maine, is focused on the development and application of computational modeling and bioinformatics methods to construct gene regulatory networks and predict network dynamics. The candidates will participate in a multidisciplinary environment and have opportunities to interact with experimental biologists within the Jackson Laboratory, the Jackson Laboratory for Genomic Medicine at Farmington, Connecticut, and outside the institution. Postdoctoral associates will have access to high-quality data measured by state-of-the-art experimental techniques, high-performance computing facilities and the largest repository of mouse resources in the world.
A postdoctoral associate position is available in the laboratory of Dr. Jennifer Trowbridge at The Jackson Laboratory in Bar Harbor, Maine, to study epigenetic mechanisms governing hematopoietic stem cell lineage commitment and how deregulation of epigenetic modifications leads to myeloproliferative disorders including leukemia. The Trowbridge Lab offers a challenging but supportive environment. Past trainees have a noteworthy track record for obtaining grant funding and fellowships. For more information, please visit: https://trowbridgelab.com.
The Jackson Laboratory is a world leader in mammalian genetics, and has a mission we are passionate about: to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
The Ke Lab invites applicants for Research Assistants to join The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA, the Ke Lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology.
We invite highly motivated individuals who are eager to acquire new knowledge and grow new skill sets in a team environment. Candidates with a background in one or multiple areas are preferred, including computational programming, cell culture, biochemistry, molecular biology, biotechnological method development, mouse genetics, neurosciences, immunology, stem cell, or cancer biology. The Research Assistant position offers a very exciting opportunity for junior researchers to grow their research experience and skills broadly and thoroughly. We strongly support research assistants for first-authorship/co-authorship in high quality publications, and firmly promote their professional career advancement.
The Ke Lab has a postdoctoral associate opening in computational biology at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in the fundamental mechanism of m6A RNA genomics; and regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models.
The Kaczorowski Lab at The Jackson Laboratory is seeking a Postdoctoral Associate to investigate mechanisms underlying susceptibility and resilience to normal aging and Alzheimer’s disease (https://www.neuro-central.com/2018/09/19/risk-resilience-understanding-role-genetics-alzheimers-disease/). Dr. Kaczorowski is an Associate Professor and the Evnin Family Endowed Chair in Alzheimer’s Research at the Jackson Laboratory – a research institution specializing in genetics and genomics in order to discover solutions for disease. Projects leverage novel mouse models, in vitro slice electrophysiology, circuit mapping and genome engineering to understand how genetic and environmental factors interact to influence learning and memory, cognitive aging, neurodegeneration, and Alzheimer’s. Sources of support include NIH, BrightFocus, The Glenn Foundation for Medical Research, as well as generous philanthropy awards in support of research and innovation in areas of normal aging and Alzheimer’s Disease.
Exceptional candidates will have the opportunity to apply for the prestigious JAX Scholar award, which supports promising early-career postdoctoral associates conducting cutting edge biomedical and basic biological research at JAX. The award includes an independent research and travel budget and a salary above our standard postdoctoral scale (https://www.jax.org/education-and-learning/pre-and-postdoctoral-program/jax-scholars
The Ke Lab is seeking a Research Data Analyst to join The Jackson Laboratory in Bar Harbor, Maine. The lab focuses on RNA, a central node of genetic information flow from DNA to protein. Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA, the Ke Lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative biotechnologies, genetics, and molecular biology. Working collaboratively with bench scientists conducting experiments, the research data analyst will use existing and develop new computational tools to analyze RNA-seq, CLIP, CHIP, DNA methylation, and proteomics datasets. Applicants are expected to have proficiency in Python, Perl, or R programming languages.
The Research Data Analyst I will be directly supervised, working closely with the manager, who will assign and prioritize projects in consultation with the analyst.
The Research Data Analyst II will work independently, apply advanced problem-solving skills, and may participate in training of Research Data Analyst I colleagues.
To learn more about the Ke Lab, please visit https://www.jax.org/research-and-faculty/faculty/shengdong-ke.
The Kaczorowski Lab at The Jackson Laboratory is seeking an Associate Research Scientist to support our ongoing research program and to develop new research projects. Our group primarily focuses on mechanisms of learning and memory, as well as genetic diseases of aging (Alzheimer’s and related dementias). The successful candidate will continue and extend studies of the molecular signatures that underlie learning and memory, and disease-related pathological changes in translational models of Alzheimer’s disease. The applicant must be a team player with exceptional organizational and project management skills, including the ability to plan, schedule, and successfully carry out multiple projects at the same time. In addition to experimental studies, the applicant is expected to participate in manuscript preparation and grant writing, and will be strongly encouraged to obtain independent funding.
The Jackson Laboratory is a world leader in mammalian genetics. JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health.
The Ke Lab is seeking a postdoctoral associate at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.)
Chemistry and physics meet biology and genomics in the Mass Spectrometry and Protein Chemistry (MSPC) Service at The Jackson Laboratory (JAX). We are seeking a Mass Spectrometry Scientist who can leverage innovative mass spec techniques, especially in the area of small molecule and metabolomics analyses, to advance JAX faculty research. Working in a high throughput, service-based facility, this position requires a high degree of independence working as a secondary interface between the facility and its users. For more information, see https://www.jax.org/research-and-faculty/tools/scientific-research-services/formal-technologies/mass-spectrometry-and-protein-chemistry.
The Mass Spectrometry Scientist is responsible for organizing, executing, and recording benchwork and database entry for user projects, including LC/MS sample preparation, method development, operation, maintenance, data analysis, and quality control. The duties and responsibilities include carrying out current and future techniques and SOPs of MSPC, as well as providing consultation and advice to investigators on future projects, new techniques, and applications.
The Tarchini Lab at The Jackson Laboratory (http://tarchini-lab.org) is seeking a Postdoctoral Associate to complete a team currently composed of two postdocs, one research assistant and rotating students or shorter term trainees. The laboratory focuses on cell polarity mechanisms and their impact on the morphogenesis of sensory “hair” cells in the mouse auditory and vestibular organs, including hearing and balance ability. We are particularly interested in discovering new protein complexes organizing and elongating the stereocilia bundle, the apical hair cell compartment capturing sound or head movements. We are also interested in understanding how these proteins respond to damage, and more generally, to ask whether the molecular machinery assembling the stereocilia bundle during development could be leveraged to regenerate these structures after injury. We are independently funded with two R01 grants from NIH.
The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research (e.g., The Nathan Shock Aging Center and Center for Novel Alzheimer’s Disease Models), unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.