The Jackson Laboratory

Postdoctoral Associate - Chang Lab

Job Locations US-ME-Bar Harbor
Posted Date 2 months ago(8/7/2020 2:12 PM)
Job ID
Scientist, PostDoctoral Associate, Professor/Faculty 


The Chang Lab at The Jackson Laboratory (JAX) is seeking a Postdoctoral Associate to investigate metabolic regulation of immune cells in the tumor microenvironment in order to benefit immunotherapy. We are especially interested in dissecting how metabolic events coordinate tumor-infiltrating T cells and control cancer progression. The project involves molecular/cellular immunology, protein chemistry, cellular signaling, metabolism, and mouse genetics. For more information see van der Windt GJ et al. Immunity, 2012; Chang CH et al. Cell, 2013; Chang CH et al. Nat Immunol, 2016; Chang CH and Qiu J et al. Cell, 2015.


The successful candidate will be expected and encouraged to develop an independent research program using the broad array of resources and expertise available to the Chang laboratory ( The candidate will leverage the extensive mouse-specific resources of JAX in combination with immunological and biochemical/molecular biological techniques, as well as advanced technologies, such as CRISPR, single-cell RNA-Seq, and other “omic”  technologies, to address his or her scientific questions. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, grant writing, mentoring and laboratory management to best prepare postdocs for future career opportunities.


The project is anticipated to provide new insights into cancer immunotherapy for high-impact publications and to generate new therapeutic concepts. Hard working candidates with the drive to succeed are encouraged to apply.


For more information about Lucas Chang and the Chang Lab Group, please visit:


  • The ability to design, execute and analyze an independent research project as well as exceptional verbal and written communication skills are expected.


  • M.D. or Ph.D. in biological or related sciences is required.
  • Strong training background in molecular biology, immunology, cancer biology, or genetics and genomics;
  • Exceptional verbal and written communication skills; and
  • Minimum of one 1st author paper from graduate work.
  • Preference will be given to self-motivated, goal-oriented, and creative individuals with a commitment to solving biological problems.

To apply, a complete application must include a cover letter describing past research accomplishments, research interests, and career aspirations; a current CV; and the names and contact information of three references.


About Us

The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,300 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center in Augusta, Maine, a genomic medicine institute in Farmington, Connecticut, and facilities in Ellsworth, Maine, Sacramento, California, and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.

JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!


Our Values:

INTEGRITY - Courage and commitment to do what is right

PEOPLE - Inspiring our people to enhance the health of all

ONE TEAM - Unified by our promise to transform medicine and science

EXCELLENCE - Achieving world-class results

INNOVATION - Leading with discovery and creative solutions

STEWARDSHIP - Caring for and enhancing the resources entrusted to us


What do we have to offer?

JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program, an onsite full service cafeteria, and a fully operational primary care facility available to employees and their families.

Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.

Employment will require successful completion of references, background check, and an appropriate non-compete agreement.

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Learn more about career opportunities at JAX:



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