Computational Postdoctoral Associate
Computational biology is critical not only to the processing and manipulation of data, but to the scientific discovery process itself. Our lab empowers computational biologists to make discoveries by providing a rich work environment for computational/mathematical analysis of biological systems, access to novel data and computational infrastructure, resources to conduct new experimental measurements, and partnerships with experimental colleagues with shared interests.
As of December 2019, the Chuang Lab is seeking a postdoctoral scientist to join our projects combining computational and experimental approaches to study cancer. Our current projects are at the intersections of cancer biology, machine learning, genomics, image analysis, and pathology. This is a fast-moving field with tremendous opportunities to understand cancer and impact patient outcomes.
New team members will have unique opportunities to investigate mechanisms of cancer, to design new studies, and to develop novel artificial intelligence approaches to mine these data. Our lab seeks to understand how tumor ecology and evolution impact susceptibility and response to immunotherapy, targeted therapy, and chemotherapy. We interrogate these questions by generating data from clinical samples and model systems (xenografts, organoids) and by mining large cancer genomic and imaging datasets using techniques such as deep learning and evolutionary modeling. This position is supported by an R01 grant from the NCI awarded through 2023.
While our lab focuses on computational approaches, we also generate our own data by making use of the extensive scientific services at JAX and in collaboration with many experimental colleagues. These include clinical and experimental groups at JAX (Robson, Palucka, Liu, Anczukow-Camarda, et al.) and with external partners (NCI PDXNet, Yale, Northwestern, UCSD, et al). We have particular access to patient-derived xenografts (PDXs) due to Prof. Chuang's position as co-PI of the National Cancer Institute's PDXNet Consortium Data Commons and Coordination Center, in addition to the extensive data and experimental resources for PDXs at JAX. Thus candidates will have novel opportunities at the intersection of data interpretation, algorithms, and experimental design.
For this position, the ideal candidate will have Ph.D. experience in computational biology, cancer biology, evolutionary biology, digital pathology, or a similar discipline. Outstanding applicants new to computational biology will also be considered as the lab has an extensive record of training candidates who originally studied in other fields, including physics, applied math, computer science, electrical engineering, and experimental molecular biology. A particular area of growth for the lab is the combination of genomic and pathological analysis, and those with a medical background in pathology but a strong interest in computational approaches are encouraged to apply. Computing (programming, data analysis, statistical inference, etc), publication, and communication skills will be essential. Across these backgrounds, enthusiasm and aptitude for computational biology are what define the lab.
Interested and qualified individuals should send a current CV, a 1-page (maximum) Statement of Research Interests and Career Goals, and contact information for 3 references to Dr. Jeff Chuang at email@example.com
The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,300 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center in Augusta, Maine, a genomic medicine institute in Farmington, Connecticut, and facilities in Ellsworth, Maine, Sacramento, California, and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup.
JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories.
In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports.
JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!
INTEGRITY - Courage and commitment to do what is right
PEOPLE - Inspiring our people to enhance the health of all
ONE TEAM - Unified by our promise to transform medicine and science
EXCELLENCE - Achieving world-class results
INNOVATION - Leading with discovery and creative solutions
STEWARDSHIP - Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program and an onsite full service cafeteria.
Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.
Employment will require successful completion of references, background check, credit check, pre-employment physical, drug test and an appropriate non-compete agreement.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
Learn more about career opportunities at JAX: http://www.jax.org/careers.