The Ke Lab has an Associate Research Scientist opening in Computational Biology at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in m6A RNA genomics:
1) Fundamental mechanism of m6A RNA genomics
2) Regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models.
(References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.)
The successful candidate will develop and apply computational methods for genomic data analyses, have novel opportunities at the intersection of algorithms, data interpretation, and experimental design in close collaboration with the experimental team in the lab. The applicant is expected to have Ph.D. in computational biology, cancer genomics, or a similar discipline, and demonstrate strong computing expertise, publication, and communication skills. We also consider exceptional applicants who are new to computational biology, including statistics, applied math, physics, and computer science.
To apply, please submit (1) a cover letter describing past research accomplishments, research interests, and career goals, (2) a current CV, and (3) the contact information of three references.
The Jackson Laboratory (JAX, www.jax.org) is a nonprofit biomedical research institute with over 2,000 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. A National Cancer Institute-designated Cancer Center, JAX has a mammalian genetics headquarters in Bar Harbor, Maine, a facility in Sacramento, California, and a genomic medicine facility, The Jackson Laboratory for Genomic Medicine (JAX-GM), in Farmington, Connecticut.
The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.
JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!
INTEGRITY - Courage and commitment to do what is right
PEOPLE - Inspiring our people to enhance the health of all
ONE TEAM - Unified by our promise to transform medicine and science
EXCELLENCE - Achieving world-class results
INNOVATION - Leading with discovery and creative solutions
STEWARDSHIP - Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program, an onsite full service cafeteria, and a fully operational primary care facility available to employees and their families.
Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
Learn more about career opportunities at JAX: http://www.jax.org/careers.